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KMID : 0361420120360010159
Journal of Korean Academy of Rehabilitation Medicine
2012 Volume.36 No. 1 p.159 ~ p.162
Cefepime Neurotoxicity in Patients with Renal Insuffi ciency
Kim Seon-Yu

Lee In-Sik
Park Seung-Lee
Lee Jong-Min
Abstract
Cefepime is a fourth-generation cephalosporin that is active against both gram-positive and gram-negative organisms. It is administered parenterally for the treatment of severe infections. Approximately 85% of the drug is excreted unchanged by the kidneys. Neurotoxicity in patients with renal failure who are treated with cefepime has been reported sporadically. We report on two senile patients with renal impairment who developed neurotoxicity including lethal outcome after treatment with cefepime.
KEYWORD
Cefepime, Neurotoxicity, Renal failure
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